Vlasova O. Morpho-functional indexes of adaptive-compensatory abilities of cardiovascular system in cronical fluoride intoxication (experimental investigation).

Object of the study: The organs of the cardiovascular system: myocardium, aorta, peripheral vessels. Purpose of the study: To increase the tendency to the changes of these disorders under the influence of calcium glycerophosphate and apple pectin. Methods of the study: Ultrastructure analysis of the myocardium of experimental animals was done using transmission electron microscopy, the intimal relief of the aorta was studied using scanning electron microscopy. Main parameters of deviations in the peripheral circulation were obtained using rheovasography. Processing of the qualitative information was done with the use of statistical methods. Practical significance: The obtained findings of the experimental studies allowed to establish that the use of calcium glycerophosphate in chronic fluorine intoxication produces slight but significant improvement of the myocardium state and cardiovascular system activity. Therefore, the use of this drug can be considered substantiated. Regular consumption of natural food containing pectin and possessing marked adsorption properties improves the morphological and functional parameters of the cardiovascular system, effectively reduces consumption of abundant amounts of fluorine. Therefore, the use of the foodstuff containing pectin as a therapeutic preventive means in endemic foci of fluorosis should be considered substantiated. Novelty of the obtained results: Complex use of modern morphological methods (serial semi-thin cuts, transmission and scanning electron microscopy) in combination with electrophysiology study (rheovasography) with statistical analysis of the obtained results provided obtaining new information about the origin and mechanism of action of fluorine at prolonged abundant consumption on the cardiovascular system of the experimental animals. The structure of myocardium was validated, it should be considered a network of connective elements integrated into a unified system by means of consequent muscular anastomoses providing generalized propagation ofdepolarization wave. The findings of the research allowed to substantiate the concept according to which prolonged abundant fluorine consumption causes disturbances of the process of generalized propagation of depolarization wave due to destruction of muscular anastomoses as well as disturbance of consequent connection between the cardiomyocytes. The obtained results can help better study the origin of morphological and functional changes in the cardiovascular system in chronic fluorine intoxication and to expand the search for therapeutic preventive measures. Introduction: The findings of the research were introduced into the teaching process of Dnipropetrovsk State Medical Academy, Ukrainian Medical Dental Academy (Poltava), Lugansk State Medical University. Sphere of application: medicine, internal diseases.