Ророva L. Neuropharmacological analyses of nootropic and hypnotic activity of GABA-ergic compounds - 1,4-benzodiazepine and 1,3,4-benzotriazepine derivatives

Тhe search for novel compounds with nootropic activity among the new 1,4-benzodiazepines and 1,3,4-benzthriazepines derivatives, comparative characteristics of hypnosedative properties of cynazepam and zopiclone. The search for nootropic activity among of 17 compunds - derivatives of 1,4-benzodiazepine and 1,3,4-benzotriazepines with different substituens in heterocycle were carried out. The data obtained have shown the perspectivity of search for novel compоunds with nootropic activity in 1,3,4-benzotriazepines row. The comparative pharmacological characteristics of cynazepam and zopiclone were realized. Results obtained on EEG-analysis of influence of cynazepam and zopiclone on sleep structure of rats were shown that both agents increased total sleep time. Publications, presentations on scientific conferences, usage of work results in researches of Research Institutes of Ukraine. Methods of investigation, pharmacologic, neurophysiologic and statistic.