Aleksandrova O. Phenazepam pharmacological properties after various methods of administration.

The pharmacological activity of the phenazepam after intravenous, oral and transdermal administration had been studied. Also were determined the features of phenazepam distribution in organs ant tissues of animals depending on the administration method. It was shown that maximum phenazepam anticonvulsive action after intravenous administration is reached during the shortest time – 10 min, though transdermal administration guarantees prolonged drug action through 48-72 hours after transdermal therapeutic system (TTS) application. The phenazepam anticonvulsive action duration depends on its concentration in TTS. The myorelaxation effect of phenazepam is noted during 0,5-5 hours after its oral administration, from 10 man to 5 hours – after intravenous administration and in 24-30 hours after transdermal administration. It was found that maximum phenazepam concentration in organs and tissues is is registered at 30 min after intravenous administration and in 5 hours – after oral administration. After transdermal phenazepam administration its concentration remains stable during 48 hours. It was shown, that combined phenazepam and phenobarbital administration is useful for intravenous and oral administrations. In these cases phenobarbital in a great degree enforces phenazepam action and causes anticonvulsive action prolongation.