Zubova E. Protective action of the xanthine derivatives in the experiment environmentof acute emotional stress .

Thesis is dedicated to study the protective action among the xanthine derivatives in the model of acute emotional stress environment. It was experimentally proved that caffeine, aminophylline and pentoxyphylline have the stress protective activity in the dose of 100 mg / kg which was given twice by intragastric way. It was shown that the most active drug is pentoxyphylline, which prevents the failures of the summational ability of CNS, the emotional and behavioural reactions, protects the hypothalamo-pituitary-adrenal axis. This action appears in the bulk retention of adrenal glands and lymphoid organs (thymus, spleen), and also in the content of ascorbic acid and 11-oxycorticosteroid in the adrenal glands, 11-oxycorticosteroid in blood plasma. Pentoxyphylline protects the gastric mucous from dystrophic failures, provides vegeto-motor balance in the brain and blood, supports peroxydant and antioxydant balance at the expense of active product of thiobarbituric acid and superoxide dismutase, stabilizes ABP and the heartbeat rate.