Petrovska G. The oxidative and conjugation reactions of xenobiotic's biotransformation in the conditions both acute and chronical inflammation processes

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0407U005046

Thesis Registration Form

0407U005046.pdf

Applicant for

Specialization

  • 14.01.32 - Медична біохімія

06-12-2007

Specialized Academic Board

Д 26.003.07

Essay

The dissertation is devoted to study the state of xenobiotic's biotransformation system in the condition of acute inflammation and chronic inflammation in rats and the patients with community-acquired pneumonia. Inflammatory process caused significant inhibition of enzymatic activity in oxidative and conjugated stages of xenobiotic metabolism, the delay of drug elimination from organism, the increase its pharmacological activity. NO-synthase inhibitors both prevent inhibition of activity of xenobiotic-metabolizing enzymes. High level of inflammatory process activity in patients with community-acquired pneumonia is associated with inhibition of metabolic transformation of diclofenac sodium and paracetamol as well.

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Дисертація-література.doc

Дисертація-розділ 1.doc

Дисертація-розділ 2.doc

Дисертація-розділ 3.doc

Дисертація-розділ 4.doc

Дисертація-розділ 5.doc

Дисертація-розділ 6.doc

Дисертація-титул.doc

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