Afanasenko O. Antioxidant properties and molecular structures of natural and synthetic phenols and N- containing heterocycles

The thesis are devoted to studying antiradical and antioxidant activities of natural and synthetic phenols and N- containing heterocycles and their relationship with structures and energetic parameters. The experiments were held in attempting antiradical and antioxidant activities of single and binuclear phenols, also pyridincarconic acids, 1,4-dihydropyridinos, nature N- containing heterocycles, S-derivative hynasolynes. Presence of positive correlations between significances antioxidant activities of tested substances, activation's energies, constants of generative speed and resonance energy of free-radicals from according substances. Among new substance - S-derivative hynasolynes according to complex of pharmacological, biochemical, quantum-chemical methods, substance - NC-109 was elected as the most powerful antioxidant. For this substance experiments "in vivo" were held, to found cytoprotective action at model of demanding liver's cells by tetrachlormethan. High antioxidant activity, stabilization of membranes, protection of gen, were showed NC-109 was injected into rats, poisoned by tetrachlormethan, and lead to correction charge of membranes superficiality, structure of proteins, during this experiment (founding of hepatoprotective effect of NC-109), not different from ionol - standard phenol?s antioxidant.