Doroshkevych I. Efficacy of thiotriazolin and lovastatin in ischemic heart disease combined with type 2 diabetes mellitus against the basic therapy of glimepiride depending on phenotype of N-acetyltransferase 2.

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0408U002337

Thesis Registration Form

0408U002337.pdf

Applicant for

Specialization

  • 14.01.28 - Клінічна фармакологія

21-05-2008

Specialized Academic Board

Д 26.550.01

Institute of Pharmacology and Toxicology of the National Academy of Medical Sciences of Ukraine

Essay

The dissertation is devoted to study the rationality of use of antioxidant thiotriazolin and the drug with metabolic activity lovastatin for increase of pharmacotherapy efficacy in ischemic heart disease combined with type 2 diabetes mellitus against the basic therapy of glimepiride considering the phenotype of N-acetyltransferase 2. The prognostic model of NAT2 phenotype determination by anthropological data was first created using mathematical modelling. The ability of thiotriazolin to inhibit significantly metabolism (acetylization) of sulfonamide test-drug was revealed.

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Files

aref_doroshkevich.doc

АНАЛІЗ І УЗАГАЛЬНЕННЯ РЕЗУЛЬТАТІВ ДОСЛІДЖЕННЯ.doc

ВІННИЦЬКИЙ ДЕРЖАВНИЙ МЕДИЧНИЙ УНІВЕРСИТЕТ.doc

ВИСНОВКИ.doc

ВСТУП.doc

РОЗДІЛ 3.doc

РОЗДІЛ 4-1-1.doc

РОЗДІЛ 4-1-2.doc

Розділ 1.doc

Розділ 2.doc

Таблиця 1.doc

вступ 1.doc

розділ 5.doc

розділ 6.doc

розділ 7.doc

список джерел.doc

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