Ilchenko A. Efficiency of clarithromycin in the complex pharmacotherapy of hospital pneumonia against a background of traumatic brain injury

The thesis solves the problem of optimizing the treatment of hospital pneumonia against the background of the traumatic brain injury by supplementary application of clarithromycin in standard antibiotic therapy, taking into account its indirect antibacterial and non-antibacterial properties. Clarithromycin (500 mg twice daily) was added to the complex pharmacotherapy of hospital pneumonia for 10 days. It was clarified that the inclusion of clarithromycin contributes to the reduction of the need for ventilation of the lungs, a significant decrease in laboratory signs of inflammation, and acceleration of X-ray dynamics. In the experimental group, the factor of tumor necrosis factor-α decreased by 44.8%, interleukin 6 - 9.0 times, and interleukin 8 - 8.9 times (p <0.05), reaching the level in patients with craniocerebral trauma without pneumonia. Additional pharmacotherapy with clarithromycin reduced the duration of inpatient treatment (by 15.1%), the average duration of ventilation of lungs (by 4.1 days), and mortality by 48.0%. It is advisable to add complex treatment of hospital pneumonia to a traumatic brain injury with clarithromycin, which will effectively eliminate not only clinical manifestations of the disease, but also positively affect the cytokine balance of patients.