Voloshenkov D. Neurotropic effects of coordinational compounds on the base of germanium oxyethylendiphosphonate with nicotinic acid, nicotinamide and magnesium (MIGU-4, 5, 6)

The peculiarities of new biologically active germanium compounds on the base of germanium oxyethylidendiphosphonate with nicotinic acid, nicotinamide and magnesium (correspondently MIGU-4, 5 and 6) influences on intact animals behaviour and electrophysiological processes as well as in neuropathological syndromes modeling were tested in the present work. All three biologically active compounds were shown to reduce motor activity, decrease muscular tone and possess anticonvulsive activity. MIGU-5, nicotinamide derivative, revealed the most expressed anticonvulsive activity in conditions of both acute and chronic seizure activity. At dose of 90,0 mg/kg it reduced seizures from 4.8 balls to 3.3 balls in conditions of pentilentetrazol kindling. Being investigated on hippocampal slices neurons MIGU-5 revealed that its anticonvulsive activity caused by both direct and recurrent inhibition potentiation in Shaffer collaterals system. Isobolographic analysis of MIGU-5 revealed its selective potentiation of valproic acid, carbamazepine, dyphenilhydantoine, topyramate, gabapentine, lamotrigine and levitiracetam anticonvulsive effects. The conclusion was made that new compounds possess neuropharmacological activity that was shown in animals as both behavioural and electrophysiological reactions change in conditions of epileptic and parkinsonian experimental models as change of cortex neurons reactivity and hippocampal slices. It causes expediency of their further profound studying as perspective anticonvulsive compounds