Kukhar O. Neurotropic properties of antibiotics at the common introduction with analgesics and nonsteroidal antiinflammatory drugs

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0408U004908

Thesis Registration Form

0408U004908.pdf

Applicant for

Specialization

  • 14.03.05 - Фармакологія

21-11-2008

Specialized Academic Board

Д64.605.01

Essay

Thesis is devoted to the experimental research of influence of narcotic analgesics and nonsteroidal antiinflammatory drugs on the anaesthetic activity of aminoglycosides and convulsive effects of fluoroquinolons. Gentamicin didn't exponentiated anaesthetic activity of diclofenac natrium, nimesulide and celecoxib, but it raised analgesia of tramadol in the dose 15 mg/kg at the model "electrostimulation of rat tail". The combined introduction of gentamicin with tramadol in the dose of 15 mg/kg changed the limen of analgesic activity almost as tramadol in the dose of 20 mg/kg. Gentamicin and moxifloxacin demonstrated prooxidant properties which were graded by antioxidant properties of tramadol in the departments of brain (cortex, hippocampus) for one and course introduction. Thus the most effective and safe combinations of analgesics and NSAIDs with antibiotics were determined experimentally for further clinical researches.

Read more

Files

автореферат-автореферат.doc

автореферат-тітул.doc

дисертація кухар чистовик-ВИСНОВКИ.doc

дисертація кухар чистовик-ЛІТЕРАТУРА.doc

дисертація кухар чистовик-РОЗД Л4.doc

дисертація кухар чистовик-РОЗД Л5.doc

дисертація кухар чистовик-РОЗДІЛ 2.doc

дисертація кухар чистовик-РОЗДІЛ1.doc

дисертація кухар чистовик-РОЗДІЛ3.doc

дисертація кухар чистовик-РОЗДІЛ6.doc

дисертація кухар чистовик-ТІТУЛ.doc

Similar theses

0422U100029

Sheikhali Ali Marsel

Experimental justification for the use of a new combined cream "Dermalipoin" for the treatment of purulent-inflammatory skin diseases

0422U100006

Dub Anastasiia Ihorivna

Experimental approach of the antidiabetic activity of the new phytocomposition

0421U102934

Stefaniv Ivan Volodymyrovych

Pharmacological characteristics of the new herbal medicine «Kasdent» for the treatment of inflammatory diseases of periodontium and oral mucosa

0421U102041

Prokopchuk Elena Gennadyevna

Complex compounds of Sn (IV) with salicyloylhydrazones of benzaldehydes as potential biologically active substances with anti-inflammatory, analgesic and concomitant pharmacological action

0521U101312

Nosivets Dmitriy Sergeevich

Pharmacological analysis of analgesia and chondroprotection in experimental osteoarthritis on the background of hypothyroidism