Pidgirny V. Experimental studies of hepatotoxic influence of antiulcerous remedies used in combinations and its correction

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0409U003232

Thesis Registration Form

0409U003232.pdf

Applicant for

Pidgirny Volodimyr V

Specialization

14.03.05 - Фармакологія

Date of defense

19-06-2009

Specialized Academic Board

Д64.605.01

Essay

Dissertation is dedicated to the study of the liver morphologic and functional state after combined using of lansoprazol (in a dose of 5,4 mg per kg), metronidazol and clarithromycin (each in a dose of 90,7 mg per kg) in healthy animals, chronic hepatitis and acute gastric ulcer as well as to the investigation of thiotriazolin (in a dose of 9,07 mg per kg) for lowering hepatotoxic action of the antiulcerous remedies It has been estimated that the use of the investigated remedies is accompanied by the divergences in the liver morphologic and functional slate, intensification of the lipid peroxidation, disturbances of antioxidant defence in healthy animals and aggravation of the pathologic deviations against the background of chronic hepatitis and acute gastric ulcer. The combined use of thiotriazolin and untiulcerous remedies reduces hepatotoxic manifestations of the last in healthy animals, against the background of chronic hepatitis and acute gastric ulcer.

Thesis supervisor

Gudyma Arsen A

Official opponents

Дроговоз ССвітлана Михайлівна
Сирова Ганна Олегівна

Files

10Analis.doc

11Vysn.doc

12Spysok.doc

13Dodatky.doc

1Tytul.doc

2ZmistPerel.doc

3Vstup.doc

4Rozdil_1.doc

5Rozdil_2.doc

6Rozdil_3_1.doc

7Rozdil_4_1.doc

8Rozdil_5_1.doc

9Rozdil_6_1.doc

avtoref--1Tytul avtoref.doc

avtoref--2Tytul avyoref.doc

avtoref--Text1 avtoref.doc

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