Renzjak S. Searching and study of antihypoxants with thermoprotective characteristics amongst 4-thiazolidines

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0409U003697

Thesis Registration Form

0409U003697.pdf

Applicant for

Specialization

  • 14.03.05 - Фармакологія

18-09-2009

Specialized Academic Board

Д 41.600.01

Odessa National Medical University

Essay

The dissertation is dedicated to the screening researches of 15 thiazolіdine derivatives with lico-like molecules, which have been chosen on the base of virtual screening with help of computer programs PASS C&T and Log/ACDLabs, which have shown that the most significant antihypoxic activity realizes compound 9-(3-ethoxy-4-hydroxyphenil)-14-(4-fluorphenil)-3,7-dithia-5,14-diaza-pentacyclo-[9.5. 1.02,10.04,8.012,16]-heptadez-4(8)-en-6,13,15-thrion with laboratory code Les-2140. Studied derivative 4-tiazolidine realizes the antihypoxic activity with thermoprotective properties by decreasing intensity of free-radical reactions, regulations of prooxidant-antioxidant homeostasis, prevention of decline in activity of such key enzymes as superoxyddismutase and catalase in blood serum and brain tissue.

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Files

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