Shepetko M. Phospholipid Vesicles (Liposomes) as Functional Modulators for Adrenergic Systems in Vascular Smooth Muscles

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0409U004464

Thesis Registration Form

0409U004464.pdf

Applicant for

Specialization

  • 14.03.05 - Фармакологія

16-09-2009

Specialized Academic Board

Д 26.550.01

Institute of Pharmacology and Toxicology of the National Academy of Medical Sciences of Ukraine

Essay

This thesis focuses on the investigation of the effects of phospholipid vesicles (liposomes) on adrenergic responses in vascular smooth muscle cells (SMC). It has been shown that liposomes possess the ability to modulate adrenergic reactions in SMC particular when its size was up to 80-100 nm. The experiments on isolated rat portal vein preparations demonstrated that small-size monolammellar liposomes can rapidly and reversibly increase the responses mediated by alpha-adrenoreceptors in SMC. This manifested in enhancement of alpha-adrenoreceptors maximal response to agonists and corresponding decrease of EC50. Small-size monolammellar liposomes can also rapidly and reversibly decrease beta-adrenoreception sensitivity in portal vein that manifested in decrease of SMC maximal response to beta-adrenoreceptors agonists. Large-size monolammellar liposomes and micellar phospholipids do not possess such ability.

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Files

DISER_Shepetko.pdf

Shepetko_aref.pdf

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