Sydorenko G. The analysis of mechanisms of formating of bioelectric activity of a cerebral cortex and hippocamp rats in the conditions of the long-term stress

On the simulated model of stress the changes of bioelectric activity of a cerebral cortex and hippocampus rats are defined and described. It is shown that in the conditions of experiment on the absolute and relative indexes of bioelectric activity of the indicated structures the delta-activity was dominant. It is established that both in physiological conditions, and in the conditions of zoodisputed stress dynamics of capacity of all investigated rhythms of bioelectric activity of a cerebral cortex and hippocampus had three-phase character. Besides it is revealed that in the conditions of the stressful program at the beginning and in the end of research absolute power of bioelectric activity of all frequency ranges of these structures of a brain had higher values comparative with similar indexes of animals of control group. The obtained data about еру dynamics of bioelectric activity of a cerebral cortex and hippocampus on a background stress and modulation synaptycal transmission by aminazine, amitriptiline and carbamazepine are specifies that despite mechanisms of action of the investigated preparations, there were the synchronising influences which can testify about gypermedyatsyy, which provides processes of self-regulation in the conditions of stress were observed. It is shown that the medicanal direct or mediated activation of the stress-limiting of system of a brain of rats occurs for the account gypermedyatsyy, which results in the increase of concentration of medyator in a synaptyc crack by stimulation of synthetic activity presynaptyc neuron, blockade of return capture of mediator or blockade of its absorption. Key words: cerebral cortex, dorsal hippocampus, zooconflict stress, bioelectric cerebrum activity, aminazinum amitriptylinum, carbmasepin.