Dovgan' R. Efficiency of biprolol at application with metaboliс drugs (quercetin, thiotriazolin) for rats with a spontaneous arterial hypertension.

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0409U004880

Applicant for

Specialization

  • 14.03.05 - Фармакологія

22-10-2009

Specialized Academic Board

Д 26.550.01

Institute of Pharmacology and Toxicology of the National Academy of Medical Sciences of Ukraine

Essay

Dissertation work is devoted to efficiency of hypotensive properties of biprolol and its compatible application with metabolic drugs (quercetin and thiotriazolin) rats with a spontaneous arterial hypertension (SAH). As a result of the conducted experimental researches influence of biprolol at three-monthly intragastric application to the rats with SAH was certain - biprolol lowered an arterial pressure on 17.7 %. Biprolol with quercetin, biprolol with thiotriazolin, and also monotherapy with biprolol lower the closeness of cardiac hystiocytes nuclei, increase concentration of RNA both in myocardium and in the cells cytoplasm of animals with SAH.

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