Kidin Y. Antidepressant-like activity of non-competitive antagonists N-methyl-D-aspartate and their mechanism of action.

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0409U004881

Thesis Registration Form

0409U004881.pdf

Applicant for

Specialization

  • 14.03.05 - Фармакологія

21-10-2009

Specialized Academic Board

Д 26.550.01

Institute of Pharmacology and Toxicology of the National Academy of Medical Sciences of Ukraine

Essay

The dissertation is devoted to find out the most active substances in the line of tienopirimidine derivatives of monocarbonic acids (compounds TSV), and study of their antidepressant-like properties in conditionals of experimental depression. In additional two more classes of noncompetitive NMDA antagonists were investigated: calcium channels blockers (memantin, midantan) and polyamine binding sites modulators (spermine, arkaine, and IEMs compounds). Polyamine binding sites modulators do not have any antidepressant-like activity in same experimental models of depression. It was shown that neither monoaminergic neither GABA systems do not plays any significant role in antidepressant action of non-competitive NMDA antagonists. However, opiate receptors blockage by naloxone can reverse anti-immobility effects of TSV 31.54, thoughts by presynaptic action on glutamate terminals.

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Files

автореферат Кидин Ю.В..doc

диссертация Кидин Ю.В..doc

диссертация Кидин Ю.В..doc

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