Nitsak O. Experimental justification the feasibility of applying a suspension of nanodispersible silica as a sorption remedy

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0409U005752

Thesis Registration Form

0409U005752.pdf

Applicant for

Specialization

  • 14.03.05 - Фармакологія

16-12-2009

Specialized Academic Board

Д 26.550.01

Institute of Pharmacology and Toxicology of the National Academy of Medical Sciences of Ukraine

Essay

The paper is devoted to the development and study of the absorption, antitoxic, hepatoprotektiv properties of the new pharmaceutical form of the drug sorption detoxication action - suspension of nanodispersible silica. As a result of experimental research, the influence of different polymer compounds on the sedimentation stability and protein sorbion activity were determined, the suspensions composition was grounded, for 100 g: nanodispersible silica - 5 g; polietylenoxyd PEO-400 - 0.5 g; water - up to 100 ml. Research of antitoxic properties of medicines showed that the suspension of nanodispersible silica by a intraperitoneum infusion refers to the V class of toxicity (practically non-toxic substances) and reduces DL50 of the potentially toxic substances: sodium nitrite, sodium ftoride and anti-tuberculosis drugs (isoniazid, rifampicin, ethambutol).

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Files

NitsakOV.doc

V-авторефератNitsak.doc

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