Semenova Y. The role of alimentary factors in phosphatidylserine metabolism regulation in brain, kidney and liver of aging rats

The object of study - age-related peculiarities of the content and metabolism of phosphatidylserine and metabolically related lipids involved in the process of aging in the brain, kidney and liver of male Wistar rats and modeling effect of alimentary factors. Purpose - to investigate peculiarities of the content and metabolism of phosphatidylserine in the process of aging in different tissues along with the modeling effect of alimentary factors on experimental and age-related changes in functional activity of the organs and the phosphatidylserine role in the processes. Methods - physiological, method of thin layer chromatography, spectrophotometeric, radioisotope methods, statistical analysis. Theoretical and practical results, innovation - it has been found that fish oil-enriched diet and exogenous phosphati-dylserine exposure prevented the decreasing of the phosphatidylserine level in hippocampus of old animals and en-hanced their learning activity. Fish oil-enriched diet normalized ethanol-induced metabolic and functional disruptions in kidneys, increased the phosphatidylserine level in hippocampus of young rats exposed to ethanol completely re-stored their cognitive function. The sphere of application - human and animal physiology, dietology, gerontology, higher nervous activity physiology.