Popenko N. The system and inhalation corticosteroidal therapy influence on the process of the bone tissue remodulation among the patients suffering from bronchial asthma

Object of research - bronchial asthma persistent flow is mild degree of severity, moderately, severe degree of severity. The aim of investigation - to increase the effectiveness of early diagnosis of complications of treatment of asthma, namely remodeling of bone tissue and predicting its occurrence on the basis of studying a number of characteristics of individual rights. Methods of research - clinical, functional, clinical-laboratory, biochemical, ultrasound densitometry and X-ray osteodensitometry, anthropometric, statistics. Results - while learning the bone tissue remodulation markers it was revealed that 47,46 % patients who suffer from bronchial asthma more than 5 years, have calcium reduction in the blood serum and increase of its excretion with daily urine. It was determined that calcium reduction in the blood serum and increase of its excretion daily urine, is observed 2 years later after the beginning of the glucocorticoides systemic taking with the dose of 10-25 mg/day. 16,95 % patients suffering from bronchial asthma have shown the real reduction of inorganic phosphorus in the blood serum. It was compared with healthy people. The use of inhalatic glucocorticoides with the dose of 500-1500 mсg/day didn't influence on changes in bone tissue remodulation markers. Osteopenic syndrome is really more developed among women who carry phenotype N and among the men-carriers of blood antigen 0(I), who have the dominative endomorphy component of somatotype. Area of application - pulmonology, therapy.