Poshyvak O. Pharmacological correction of immune system by thiazolidon derivates in experimental immunodeficiency

The dissertation is dedicated to the problem of searching of potential means with immunostimulating activity among thiazolidon derivates. On the base of pharmacological studies, grounded by virtual screening, a group of non-toxic lead-compounds which are characterized by high immunomodulating activity was chosen. Studied thiazolidon derivates possessed high activity in treating of cyclophosphan immunodeficiency comparing to the standard therapy (using polyoxidonium). It was confirmed, that there using leads to increasing of immune system basic morphological parameters (body weight, thymus and spleen mass and mass index), activity of phagocytosis, CD3, CD4, CD16, CD22 cells levels in animals with immunodeficiency. Also, increasing of IgA, IgM and IgG quantity was observed. Highly active lead-compound (LES 5849) among tiazolidon derivatives based on immunotropic activity was identified. The data obtained let us to enhance present spectrum of means - potential drugs with immunomodulating properties.