Mykytenko D. The significance of the methylenetetrahydrofolate reductase polymorphisms for development of the pathology of pregnant and/or fetus.

Dissertation is devoted to study of the prevalence among women giving birth in Kiev region of the polymorphisms C677T and A1298C of methylenetetrahydrofolate reductase gene (MTHFR), determine their clinical relevance for the development of pregnant pathology and fetus condition. It is determined the frequency of MTHFR alleles among the studied cohort of mothers and extrapolated data at the level of the Kiev region. It is determined the connection of the 677 mutant T-allele carrying with the development of threats of miscarriage and gestosis of second half of pregnancy. The communication between carrying of A1298C polymorphism of MTHFR gene with pathology of pregnant and fetus was not found. It is shown that the mutant alleles at 677 and 1298 MTHFR sites can not simultaneously situated at the same chromosome through a phenomenon of linkage disequilibrium. It is proved the effect of individual outer factors on the occurrence of pregnant pathology and fetus condition. It is substantiated the selection of risk groups of women on the development of MTHFR-associated pathology. It is suggested the practical recommendations regarding to the improvement of periconceptual prevention of the pregnant and the fetus pathology.