Muzyka N. Experimental Grounds for Clinical use of Unique Phytogenous Prostate-Protective Means -Altabor Suppositories.

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0410U002247

Thesis Registration Form

0410U002247.pdf

Applicant for

Specialization

  • 14.03.05 - Фармакологія

02-04-2010

Specialized Academic Board

Д64.605.01

Essay

Study of sulfochlorination of 4-methyl-1,2-dihydroquinolin-2-one derivatives with substituents in benzoic ring has been done for the first time. In order to find new biologically active substances рreparative methods for obtaining of 4-methyl-2-oxo-1,2-dihydroquinolin-6-sulfonylamides, 6-alkylsulfonyl-4-methyl-1,2-dihydroquinolin-2-ones and 4 methyl-2-oxo-1,2-dihydroquinolin-6-sulfonylacetic acid amides have been developed and wide series of these compounds have been synthesized. Alkylation of 4-methyl-2-оxо-1,2-dihydroquinolin-6-sulfinic acid with allylbromide has been investigated. It has been found that the product of this reaction, depending on conditions, is the corresponded allylsulfone or its mixture with isomeric propenylsulfone. Antimicrobial, diuretic, haemostatic and anticoagulant activity of new compounds has been studied, some structure-activity relationships have been revealed. As a result, 4 methyl-7-chloro-2-оxо-1,2-dihydroquinolin-6-sulfonic acid n-butylamide, which has potent diuretic activity, has been proposed for profound biological research.

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Files

Autoreferat.doc

Titul.doc

дис_Музика Н.Я--Висновки.doc

дис_Музика Н.Я--Літературa.doc

дис_Музика Н.Я--Підсумок.doc

дис_Музика Н.Я--Титул_зміст_введ.doc

дис_Музика Н.Я--роз.2 матеріали і методи.doc

дис_Музика Н.Я--роз1.Огляд літ.doc

дис_Музика Н.Я--розділ 3.doc

дис_Музика Н.Я--розділ 4.doc

дис_Музика Н.Я--розділ 4.doc

дис_Музика Н.Я--розділ 5.doc

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