Object of research: the clinical and functional state of organism of cows is depending on influence of unfavorable technological and ecological factors. Purpose of research: to learn the ecological features of area of location of economies, technological terms of maintenance of cattle, clinical state of animals; influence of seasonal, ecological and technological factors of maintenance on the haematological indexes of cows; influence of ecological and technological factors is on the histological structure of liver; efficiency of feeding with vitamin-mineral mixtures with the purpose of diminishing of influence of unfavorable factors of environment on the organism of animals. Methods of research: atomno-absorbtsiyni, hygienic, clinical, haematological, histological, zootechnic, statistical. Scientific novelty: the complex study of hygienical terms of maintenance, morphological composition and biochemical indexes of blood, histological structure of liver is first conducted for cows depending on the season of year, terms of feeding, technological and ecological factors of area of activity of DP "L'vivvugillya". It is well-proven that of feeding with to the cows of mixture of deficit in a ration micro-, macronutrients, vitamins and methionine positively influenced on normalization of processes, functional state of organism and, above all things, liver. To the scientific novelty of the conducted researches the got patent of Ukraine testifies on an useful model № 31874 from a 25.04.2008. "Method of correction of processes of exchange of matters and functional state of liver of cows in the conditions of technogenic contamination of environment " Subject and degree of providing: a patent is got on an useful model and practical recommendations are offered in relation to the methods of estimation of the functional state livers of cows, which are retained in the areas of activity of enterprises гірничо extractive to industry Patent № 31874 Ukraine on an useful model, U200713951, MPK (2006), A01K67/00. Proposed: in a stall period to apply the table of contents vitamin-mineral mixture for the correction of processes of exchange of matters and functional state of liver, additional receipt of deficit micro-, macronutrients, vitamins in an organism, diminishing of negative influence of technogenic contamination of environment, increase of the productivity of cows. Introduced: in PAF "Ostriv" of Sokal'skogo to the district, DPDG "Radekhivske" Radekhivskogo to the district of the Lviv area. Sphere (field of using): veterinary medicine, animal physiology, hygiene and animal health.
