The thesis is devoted to a comparative sanitary and hygienic assessment of the use in feeding broiler chickens of two feed additives made from waste of primary processing of marine aquatic organisms by determining their effect on safety, productivity, the main indicators of nonspecific immunity, protein and mineral metabolism, bone strength and meat quality. Free feeding of a mineral feed additive in the form of coarsely crushed valves of sea mussels caused changes in the parameters of macro- and microscopic structures of the digestive organs of chickens, indicating the development of protective and adaptive reactions in response to mechanical irritation of the esophagus and stomach walls and a high calcium content in the chyme of the small intestine. According to the results of physico-chemical studies, it was found that MA contained more dry matter and calcium, while PMA contained more crude protein and phosphorus. According to the results of microbiological and toxicological studies, it was found that microbial contamination of extracts from feed additives the number of mesophilic anaerobic and facultative anaerobic microorganisms is less than boundary permissible level, it does not contain enteropathogenic bacteria of the E. coli group, Salmonella, staphylococci, toxin-forming anaerobes and Proteus, as well as did not affect the clinical state of white mice and mobility cultures of ciliates Colpoda steinii. The use of broiler chickens of a protein-mineral additive (PMA) made from the valves and bodies of sea mussels, as well as red algae and sea water contributed to a significant increase in the body weight of broiler chickens by replacing it with part of the diet by 2.7% and by enriching it by 4.5%. The use of a mineral supplement (MA), which contains only the valves of sea mussels, did not significantly affect the growth rate of chickens. Enrichment of the main ration of feeding chickens with MA and PMA in an amount of 7% higher than its mass caused changes in the microscopic parameters of the duodenum, which indicates an increase in its functional activity. When PMA was used in the diet of broiler chickens, a significant increase in the hemoglobin content in the blood and a tendency to an increase in the number of erythrocytes and leukocytes were observed, which indicates an increase in the state of nonspecific immunity. The use of feed additives in chickens contributed to an increase in the intensity of protein metabolism: an increase in the serum content of total protein, albumin and globulin, as well as transamination enzymes – alanine and aminotransferase. In the blood serum of chickens from the experimental groups, there was a significant increase in the content of inorganic phosphorus, a decrease in the calcium-phosphorus ratio and the content of alkaline phosphatase, which indicates the effect of feed additives on the state of mineral metabolism. The use of feed additives contributed to an increase in the content of inorganic calcium and total phosphorus in the bone tissue of chickens, a decrease in the calcium-phosphorus ratio and an increase in the strength of the tibia. Feeding broiler chickens with PMA in addition to the main diet contributed to an increase in the quality of meat, as evidenced by the significantly higher content of dry matter in minced meat, protein, tryptophan in its composition, and also a protein quality indicator.
