Glotka L. Genetic character of Hypothalamic syndrome of puberty in boys

1. Object of study: immunogenetic and dermatoglyphic characters at the hypothalamic syndrome of puberty in adolescent boys. Objective: studying immunogenetic and dermatoglyphic characters in boys with hypothalamic syndrome of puberty for improving the prognosis of the disease formation. Methods: genealogical, immunogenetic, dermatoglyphical, and statistical. Theoretical and practical results: There is presented an original solution of a scientific problem connected with studying the role of immunogenetic and dermatoglyphic signs in prognostication of HSP formation in boys. Statistically significant differences in frequency distribution of I class antigens of the HLA system as compared with such characters in healthy persons are firstly established in boys with HSP. In adolescents with different HSP forms or with its unfavourable course there are revealed positive or negative associative relations between certain antigens and the pathology. There are singled out the HLA system antigens which can cause HSP development or prevent the disease onset. There is established the existence of statistically significant distinguishing features in quantitative and quantitative dermatoglyphic characters in boys with different clinical variants of HSP or at its unfavourable course. There are revealed similarity's or differences in distribution of immunogenetic and dermatoglyphic characters in the nuclear families, members with boys, having HSP. There is obtained some evidence of immunogenetic and dermatoglyphic characters significance at HSP, there are singled out and approved some criteria of HSP, of its prognostication, course, and clinical variants in boys. There is substantiated the use of immunogenetic and dermatoglyphic characters as prognostic criteria of HSP formation. Their significance in prognosis disease totals 62% according to the Vald's method. Employing certain immunogenetic and dermatoglyphic markers HSP in boys will contribute to revealing persons with a high risk of the disease formation during medico-genetic consulting. Application field: genetics.