Pidlisna V. Monitoring of the captopril safety profile in patients with arterial hypertension.

The aim of this dissertation is to determine the incidence of drug side effects when patients are subject to pharmacological supervision. Such supervision permits a more objective estimation of the incidence of side effects compared to estimation based on spontaneous notifications. We monitored ambulatory patients and in-patients to determine the side effects/efficiacy of Captopril. We monitored several patients groups that are at risk of developing side effects and took steps to insure our patients took their drugs in the safest possible environment. We discovered that in-patients are much more compliant with pharmacotherapy than ambulatory patients. In both patient groups, there was a clear tendency for the efficacy of Captopril to decrease and incidence of side effects to increase with the duration of hypertension. The efficacy and safety of Captopril monopharmacotherapy in in-patients were significantly higher than during combined pharmacotherapy.