Shatilova O. Molecular pharmacological grounds of interaction alpha1-adrenergic blockers with receptors, albumin and DNA

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0410U006146

Thesis Registration Form

0410U006146.pdf

Applicant for

Shatilova Olga Andriyivna

Specialization

14.03.05 - Фармакологія

Date of defense

29-10-2010

Specialized Academic Board

Д 64.605.03

National University of Pharmacy

Essay

QSAR-models for predicting alpha1-adrenoceptor blocking activity of aporphine and arylpiperazine derivatives by quantum-chemical and topological descriptors were developed. Predictive value of models has been proved in studies on isolated rats' vas deferens. It was shown, that interaction of human serum albumin with doxazosin causes significant conformational rearrangement of albumin molecules. Amino acids of doxazosin binding center in albumin and alpha1A-adrenergic receptor are defined. In experiments on cells cultures cytotoxic properties of alpha1-adrenergic blockers has been studied. The interaction of doxazosin with the DNA double helix as intercalator has been proved.

Thesis supervisor

Chekman Ivan Sergeevich

Official opponents

Дроговоз Світлана Мефодіївна
мець Ігор Ігорович

Files

aref.doc

dis_Nebesna.doc

Similar theses

0422U100029

Sheikhali Ali Marsel

Experimental justification for the use of a new combined cream "Dermalipoin" for the treatment of purulent-inflammatory skin diseases

0422U100006

Dub Anastasiia Ihorivna

Experimental approach of the antidiabetic activity of the new phytocomposition

0421U102934

Stefaniv Ivan Volodymyrovych

Pharmacological characteristics of the new herbal medicine «Kasdent» for the treatment of inflammatory diseases of periodontium and oral mucosa

0421U102041

Prokopchuk Elena Gennadyevna

Complex compounds of Sn (IV) with salicyloylhydrazones of benzaldehydes as potential biologically active substances with anti-inflammatory, analgesic and concomitant pharmacological action

0521U101312

Nosivets Dmitriy Sergeevich

Pharmacological analysis of analgesia and chondroprotection in experimental osteoarthritis on the background of hypothyroidism