Shatilova O. Experimental study of Diacamph cerebroprotective and psychotropic properties

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0410U006147

Thesis Registration Form

0410U006147.pdf

Applicant for

Specialization

  • 14.03.05 - Фармакологія

29-10-2010

Specialized Academic Board

Д 64.605.03

National University of Pharmacy

Essay

Diaсamрh increases survival, reduces neurological deficit and improve hystostructure of brain cells. In animal model craniocerebral trauma. Diacamph doesn't show muscle relaxant, tranquilizer, anxiolytic activity on intact animal, however it has an antidepressant, antiaggression, nootropic, antialkoholic effects. Diacamph exceeds piracetam on all models. Dose-dependent action of Diacamph is identified in dose range from 10 mg/kg till 50 mg/kg, effective cerebroprotective and psychotropic dose is 25 mg/kg. Cerebroprotective and nootropic effects are associated with antioxidant effect and the stimulation of imidazoline receptors. The analysis of Diacamph's action shows increase of brain dopamine level.

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Files

Шатилова Автореферат.doc

Шатилова диссертация.doc

Шатилова диссертация.doc

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