Pakhomova A. Influence of quercetin on the congenital and got behavioural reactions of rats with alcoholic intoxication

The thesis is devoted studying of a physiological role of quercetin in the organization congenital and got behavior intact rats and rats with alcoholic intoxication, and also to studying of its influence on change lipids peroxidations of in fabrics of a liver and a brain of animals with a corresponding alcoholic intoxication. Influence of antioxidant of quercetin is first investigational on the innate and purchased behavioral reactions of rats with the different models of alcoholic intoxication. It is set that the sharp and chronic alcoholizing renders substantial influence on activity of organism, which shows up both in violation of adaptation behavioral reactions and in the change of activity of the antioxidant systems of organism. Two-week application of quercetin is first examined as a potential mean of diminishing of consequence to sharp and chronic alcoholic intoxication. Dependence of normalization influence of quercetin is also shown on a chart and duration of his reception, and also type and duration of alcoholic intoxication. Contributions got in particular about normalization influence of nondurable introduction of quercetin on innate and purchased behavioral activity of alcoholizing rats and on a level of lipids peroxidization in their fabrics of brain and liver. However it should be noted that on conditions of separate long introduction of quercetin his influence on innate and purchased behavioral reactions, and also the level of lipids peroxidization in fabrics was similar to the action of the 30-daily chronic alcoholizing. It is also necessary to take into account and that on conditions of the combined nondurable application of quercetin and ethanol the indexes of behavioral activity and level of lipids peroxidization was normalized. Key words: quercetin, congenital and got behavioural reactions of rats, alcoholic intoxication, lipids peroxidation.