Markova O. Pharmacological correction of liver bioenergetical processes in posterity of animals exposed to externally induced stress

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0411U002777

Thesis Registration Form

0411U002777.pdf

Applicant for

Specialization

  • 14.03.05 - Фармакологія

08-06-2011

Specialized Academic Board

Д 41.600.01

Odessa National Medical University

Essay

The dissertation is focused on studying new methods of prophylaxis of post-radiation and stress induced disorders of bio-energetic processes in hepatic tissue and red blood cells; morphofunctional changes in hepatocytes induced by combined administration of preparations of ?-lipoic acid and thiotriazolinum are evaluated. Novel properties of ?-lipoic acid were outlined, namely the prevention of stress- and radiation induced inherited effects. Particularly, the number of animals with unstable genome in posterity of ?-irradiated rats was found to decrease. New properties of ?-lipoic acid and thiotriazolinum combination were discovered — prevention of bio-energetic processes disorders, prevention of cellular population kinetics and hepatocytes mitotic activity, prevention of erythrocytes peroxide resistance in posterity of rats exposed to multiple stress.

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Files

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