Lykhota O. The pharmacokinetics of short-chain fatty acids and exogenous metabolic derivatives

The official version of ADMET Predictor ™ predicted physicochemical and biopharmaceutical characteristics short-chain fatty acids (SCFA) and their derivatives, the need for further experimental study of these compounds are computer simulations using. The solubility, distribution coefficient octanol/water, molecular diffusion coefficient, kinetic constants, Mihaeles-Menten equation for the reaction of hydroxylation, the optimal dose of compounds for oral and intravenous administration and other properties have been established. Radiometric methods studied the processes of absorption, reabsorption, and the intrahepatic circulation of compounds in a physiological system (blood ? gastrointestinal tract). For all compounds characterized by the reabsorption, as well as “enterohepatic” circulation.The transit SCFA and their derivatives along the gastrointestinal tract in experimental animals were studied. Analysis of the relationship between the physical and chemical properties of compounds and the nature of mass transport in the body of white mice showed that the absorption of alcohols, aldehydes and acids occurs by passive diffusion.