Dubkovska M. Molecular-genetical mechanisms of impairment of psychomotor development in children with congenital cytomegalovirus infection

The dissertation dedicated to a problem of design of prognostic markers of congenital cytomegalovirus infection streaming in children first year of age. A review of the patients' medical notes have been retrospectively carried out, prospective studies were made. Comprehensive investigations consisted from clinical, laboratory, genetical studies. Clinical streaming of cytomegalovirus infection in children with intrauterine transmission were investigated with detection of the most significant clinical signs. Molecular investigations of gene GJB, encoding connexin 26, assessment of psychomotor development using Vineland behavior scales, assessment of hearing using objective audiometry with registration of auditory brain stem response were carried out. Taking into accordance with risk factor analysis it was revealed the most significant of them which may affect on intrauterine transmission of cytomegalovirus from mother to child. The most significant risk factors are regular contact of pregnant women with children of early age. It was revealed the connection of gene GJB2 mutations, encoding connexin 26, viral load and psychomotor development disorders and sensorineural hearing loss. It was established the prognostic markers of psychomotor development disorders and hearing loss in children with congenital cytomegalovirus infection.