Medvedyev B. Hypoglycemic activity of adiachrom, a new synthetic derivative of benzopiran

This thesis is dedicated to study of the complex pharmacological actions of adiachrom aimed at correcting the basic indicators of metabolic syndrome that accompanies type 2 diabetes. It was found that 15 mg/kg dosage of adiachrom has antioxidant, anti-inflammatory and membrane stabilizing effect both in intact animals and in animals with experimental diabetes. On experimental models of diabetes (nutritional as well as induced by streptozotocin, alloxan and dithizon) it was found that adiachrom shows hypoglycemic, hypolipidemic and antioxidant effects, and proved that the established effects of adiachrom are competitive to the comparative drug metformin. It was demonstrated that the mechanism of its action is associated with increased glycolysis, decreased gluconeogenesis and increased liver function during alloxan induced diabetes. It was found that adiachrom reduces glycated haemoglobin, improves rheological and antioxidant properties of blood in animals with experimental