Skvirsky A. Character of bone effects of atorvastatin, atenolol and hydrochlortiazid by the condition of experimental osteoporosis

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0412U002721

Thesis Registration Form

0412U002721.pdf

Applicant for

Specialization

  • 14.03.05 - Фармакологія

30-05-2012

Specialized Academic Board

Д 26.550.01

Institute of Pharmacology and Toxicology of the National Academy of Medical Sciences of Ukraine

Essay

The dissertation is dedicated to the evaluation of efficiency of influence atorvastatin, atenolol, hydrochlortiazid together with calcium and vit.D3 on bone tissue, in order to increase safety of administration. The effect was studied on model of osteoporosis. We observed three groups of female rats: young (6-month-old), old (18-month-old) and rats subjected to ovariectomy (OVX), after one month administration only calcium and vit.D3, and calcium and vit.D3 with atorvastatin, atenolol, hydrochlortiazid respectively. Measurement of bone mineral density at various skeletal sites in the animals were obtained by dual energy X-ray absorptiometry (DXA). We also have researched markers of bone metabolism in blood and urine. We learnt that atenolol with calcium and vit.D3 administration didn't showed any changing in BMD total of OVX rats. Whereas BMD total of old animals has decreased. According to blood and urine markers activity of destructive anabolism in all groups of rats with osteoporosis dropped.

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Files

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РАЗДЕЛ_1_2012.doc

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РАЗДЕЛ_5_2012.doc

РАЗДЕЛ_6_2012.doc

СПИСОК ЛИТЕРАТУРЫ.doc

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