Pogorila I. Neurophilic effects of peptidamidobenzophenone derivate

The influence of peptidamidobenzophenone derivate (PABPhD) upon the development of corazol-inducted kindling syndrome have been investigated. The maintenance of anticonvulsant efficiency of PABPhD upon postponed kindled seizures have been established. On the models of maximal electro-shock seizures the effective dosage (ED50) of PABPhD, which protects half of rats from generalized seizure fit was less than such one determined for diazepam by 3,1 times. The less value of effective dosage of PABPhD when compared with such one of diazepam was revealed on the models of kainat- and corasol-induced of acute seizures. Maintenance of anticonvulsant action was well-proven for rats that were tolerant to the action of diazepam. Behavioral disturbance in kindled rats which have been observed in swimming test have been abolished succesfully by PABPhD, and this effect was observed in grater range of dosages (0,15-1,5 mg/kg, i.p.) than diazepam. The antiaggressive activity of PABPhD in the test of threshold of fights in pairs of rats on electrode floor have been established. The restoration of paradoxal sleep, reduction of number of it’s episodes in kindled rats, reduction of opiate- determined components of postseizure depressive syndrome have been seen after PABPhD administration to kindled rats. Also PABPhD more effectively protected active avoidance reaction in rats during postseizure period when compared with the effectiveness of diazepam. It was shown that PABPhD caused the increase of the high-frequency beta and gama bandwidth bioelectric oscillations power in frontal brain cortex, and this effect was more pronounced that in case of diazepam administration.