Kiryachenko S. Molecular genetic markers of development risk of severe perinatal pathology in the newborns

The thesis is devoted to the study of the gene and gene-genes interaction role in the development risk of severe perinatal pathology and critical states in the newborns. We determined the association of DD genotype in ACE gene and CC genotype in AT2R1 gene, 308AA, 308AG in TNF-a gene with increased development risk of perinatal pathology, perinatal hypoxic damage, RDS, NEC, neonatal jaundice. 677TT genotype of MTHFR gene was associated with reduced gestational age and the development risk of severe perinatal pathology including critical states in premature babies. The study is based on the gene-gene interaction investigations, which takes into account the interaction between ACE, AT2R1, TNF-a, MTHFR genes. The statistical model with high predictive value was elaborated. It was shown that genetic analysis is promising approach for using in clinical practice. It may help to allocate the risk of perinatal pathology and critical states among newborns immediately after birth, before the onset of clinical manifestations of neonatal diseases.