Danylov S. Experimental study of psychotropic and neuroprotective properties of the novel motherwort pharmacological preparation.

The thesis is dedicated to the revelation of the novel motherwort pharmacological preparation - the dry tincture, obtained from the officinal tincture by replacing of ethanol with sucrose. It has been shown that the dry tincture exerts higher sedative effect than officinal one in the intact mice, on the original model of psychomotor agitation, caused by thiosemicarbazide, and in caffeine-induced excitation. It has been established that this sedative effect is dose-dependent; the relatively effective dose is 2.5 g/kg (equal to 50 mg/kg substances extracted from plant raw). The dry tincture on the basis of mannitol does not cause sedation. A weak anxiolytic effect has been revealed in subsedative doses (1 g/kg of dry tincture and 2.5 g/kg of officinal tincture). The dry tincture differs from the officinal one with the absence of the worsening of movement coordination and physical endurance and of the increase in ethanol and thiopental CNS oppression as well as with ability to improve memory. Both drugs render an anticonvulsive effect. The dry tincture, in contrast to the officinal one or bilobil, has a cerebroprotective effect in brain trauma. The dry tincture does not increase the content of GABA in the brain. It exerts moderate antihypoxic and antioxidant effects. It belongs to the VI toxicity class surpassing the officinal tincture (V class) by safety. The results experimentally substantiate the expediency of the motherwort drugs creation on the basis of dry tincture that is devoided of ethanol side effects.