Yoltukhivskyy M. Pathogenetic role of violations of sulfur-containing amino acids metabolism in the development of cisplatin-induced nephropathy

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0413U001291

Thesis Registration Form

0413U001291.pdf

Applicant for

Yoltukhivskyy Mykola Mykhaylovych

Specialization

14.01.32 - Медична біохімія

Date of defense

17-01-2013

Specialized Academic Board

Д29.600.03

Essay

The dissertation is devoted to the investigation of the biochemical mechanisms of cisplatin-induced nephropathy in rats which is associated with violation of sulphur-containing amino acids metabolism and elaboration of approaches to correct this complication. It is proved that homocysteine thiolactone-induced hyperhomocysteinemia and administration of inhibitor hydrogen sulfide-producing enzyme cystathionine-gamma-lyase propargylglycine potentiate caused by cisplatin nephropathy. The use of vitamins В6, В9, В12 with hypohomocystinemic action and exogenous donor of hydrogen sulfide sodium hydrosulfide counteract this complication.

Thesis supervisor

Lutsyuk Mykola Borysovych

Official opponents

Корда Михайло Михайлович
Савченкова Лариса Василівна

Files

aref.doc

dis.doc

Similar theses

0419U002820

Onishchenko Anatolii I.

The role of profibrotic, proinflammatory and prooxidant factors in the biochemical mechanisms of chronic rhinosinusitis development

0419U000268

Povkh Viacheslav Leonidovych

The role of NNDA-receptor modulators in the mechanisms of neuroretinoprotection in ischemic and traumatic injuries of a visual analyzer (experimental research)

0418U000910

Ivanochko Ruslana Bohdanivna

The status of L-arginine / NO-synthase / arginase system and features of oxidative processes in patients with chronic renal failure under conditions of hemodialysis.

0418U000117

Nekrut Daria Oleksandrivna

The role of insulin-like growth factor-1 and hydrogen sulfide in the mechanisms of progression and correction of non-alcoholic fatty liver disease, associated with hyperhomocysteinemia.

0417U003533

Shmulich Olesia Vadymivna

Features of metabolic profile and hormonal regulation in children with atopic diseases.