Dobrelіa N. Experimental basis for using phosphatidylcholine liposomes in arterial hypertension of various origins.

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0413U002568

Thesis Registration Form

0413U002568.pdf

Applicant for

Dobrelіa Nataliya

Specialization

14.03.05 - Фармакологія

Date of defense

17-04-2013

Specialized Academic Board

Д 26.550.01

Institute of Pharmacology and Toxicology of the National Academy of Medical Sciences of Ukraine

Essay

The thesis is devoted to validation of the feasibility of using phosphatidylcholine liposomes for correction of experimental arterial hypertension of various origins. Studies were conducted on intact rats and rats with arterial hypertension induced in various models: inherited spontaneous hypertension, arterial pressure increase due to radiation exposure, renovascular hypertension and arterial hypertension induced by inhibition of myoendothelial gap junctions. The obtained data demonstrate the feasibility of use of phosphatidylcholine liposomes in cases, when endothelial dysfunction is a main component of the development of arterial hypertension.

Thesis supervisor

Khromov Alexandr Stanislavovich

Official opponents

Французова Стелла Борисівна
Горчакова Надія Олександрівна

Files

aref.doc

dis.doc

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