Zakharchenko V. Retention placenta in cows (etiology, pathogenesis, treatment and prophylaxis)

Object of research: retention placenta in cows. The purpose of researches: The purpose of researches: is determine the role of endogenous and exogenous factors in the retention placenta's etiopathogenesis in cows on the basis of biochemical blood analysis and fetal part of the placenta and develop therapeutic and prophylactic measures. Research methods: cinical, biochemical, immunofermental, bacteriological, histological, mycological, statistical. Scientific novelty. Through the complex approach to the study of endogenous and exogenous factors in the cows' retention placenta etiology and indicators of protein-lipid, hormone, mineral and connective tissue metabolism of dry cows and postpartum detect a new pathogenic mechanisms that made it possible to justify and develop methods for prevention and sick cows treatment. In conducting research for the first time studied the connective tissue metabolism in the serum and placenta's cotyledonal and prove their pathogenic role in the development of pathology third stage of the birth. It has been stated relation between abnormality of the connective tissue metabolism and histological changes in the placenta, that leading to the retention placenta. For the first time in a comparative aspect tested and proven umbilical cord blood efficacy as a means of nonspecific stimulatory therapy for complex conservative treatment of retention placenta in cows, and its application for prevention. Degree of introduction: It has been established a number of predisposing factors in the etiology retention placenta in cows. The research's results of protein-lipid, mineral, connective tissue, hormonal metabolism, the uterus' microbial contamination and histological changes in the placenta made it possible to add the pathogenesis retention placenta in cows and on the it basis develop and recommend to the implementation scheme of preventive retention placenta in cows and treatment. It has been prove effectiveness to use of conservative treatment for retention placenta in cows with cord blood as a means of non-specific stimulatory therapy in combination with intrauterine administration of probiotic "Supozyt plus" and intramuscular uterotonic and anti-inflammatory drug dotsytol. It has been prove expediency of preventive measures in the dry period with the use of adsorbents ("Kormosan" and "Mycosorb") in the farms with a high degree of feed contamination by microscopic fungi spores and their toxins, and intramuscular injection of cord blood immediately after the birth of the calf, reduce the frequency retention placenta. On results of the researches were created "The methodical recommendations for the treatment and prevention the most common obstetric and gynecological diseases on the basis of feed contamination by microscopic fungi spores and their toxins", which have been approved by the Scientific-Methodical Council's the State phytosanitary service of Ukraine (protocol № 4 dated 21-th December, 2011). The materials of the researches are being used during studying of subject "Obstetrics, Gynecology and Animal Reproduction Biotechnology with basis of Andrology" on the Veterinary medicine faculties of the agrarian university III-IV accreditation levels (Bila Tserkva National Agricultural University, Lugansk National Agrarian University, Zhytomyr National Agroecological University, Sumy National Agrarian University). The scientific novelty of these developments is confirmed the patent of Ukraine on useful model "The method to prevent of the retention placenta in cows by using the cord blood" (The number of State registration is 4268/ZU/12 on 27.02.12. ). Sphere (industry) of the use: veterinary medicine.