Koyro O. «Role of goutweed (Aegopodium podagraria L.) biologically active substances in nephroprotective, hepatoprotective and hypouricemic activity »

The thesis is dedicated to the investigation of comparative effectiveness of nephro-, hepatoprotective and hypouricemic actions of the biologically active substances and preparations, obtained from the goutweed roots, flowers and leaves, under the conditions of toxic and ischemic injury of the liver and kidney as well as their influence on uric acid exchange. It has been proven that the leaves extract (1 g/kg) the rhizomes extract (1 g/kg), goutweed leaves protein-polysaccharide complex (200 mg/kg) and flavonoid trifolin (50 mg/kg) exert significant nephroprotective activity reducing lethality, hyperazotemia and proteinuria, eliminating anuria, counteracting glomerular filtration decrease, normalizing histopathological kidney structure. The extract (1 g/kg), goutweed leaves protein-polysaccharide complex (200 mg/kg) and trifolin (50 mg/kg) are the most effective hepatoprotective agents that improve survival rate, suppress cytolysis and lipid peroxidation, activate antioxidative system, maintain liver glycogen and protein synthesis. The beneficial effect of biologically active substances and preparations, obtained from goutweed, on uric acid metabolism under the normal conditions and in hyperuricemia has been established. It was found that the goutweed drugs differ in hypouricemic action that is obviously due to the peculiarities of phytochemical composition and biopharmaceutical factors. This action it is realized through xanthine oxidase inhibition, increase in renal uric acid excretion or through combination of both mechanisms. Thus, the results experimentally substantiate the expediency of nephro-, hepatoprotective and hypouricemic drugs development on the basis of the goutweed.