Lutsak I. Experimental study of adaptogenic properties of aspen bark extract

The work is devoted to the study of adaptogenic properties of the aspen bark aqueous extract. Research showed that it contains less bioactive substances which possess stimulating influence (simple phenols transferred into salidrozid) if compared to liquid rhodiola extract, surpassing it in the content of the anti-inflammatory substances (flavonoids, tanins). There was determined a conditionally effective dose of the aspen bark extract 1 g/kg, which stimulates motional and exploratory activity with sedative effect, improves physical endurance, lowers weariness and raises resistance to low temperatures, not yielding and even surpassing liquid rhodiola extract in the adaptogenic dose of 1 ml/kg. Adaptogenic effect of aspen bark extract also includes antihypoxic influence on the hemic hypoxia models, stress-protective action on the acute and chronic immobilization stress models according to functional, morphological (reduction of the deviations in heart hysto-structure, skeletal muscles and adrenal glands) and biochemical criteria (normalization of carbohydrate and energetic exchange in the skeletal muscles and liver as well as prooxydative-antioxydative balance, elimination of hyperglycemia and lactic acidosis). Aspen bark extract possesses moderate antidepressive and positive mnemotropic activities, shows antagonism to ethanol, and does not raise the effect of proconvulsants (corasol). The expediency of creation of a new adaptogenic preparation from the aspen bark extract has been proven experimentally.