Lytovchenko O. Structural and functional characteristics of major outer memrane protein of different sepotypes of Chlamydia trachomatis for development of molecular diagnostic of chlamydiosis.

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0414U001429

Thesis Registration Form

0414U001429.pdf

Applicant for

Specialization

  • 14.01.32 - Медична біохімія

23-12-2013

Specialized Academic Board

Д 29.600.03

Essay

The thesis is devoted to the study of polymorphism of the structure of the main outer membrane protein of Chlamydia trachomatis. It was established that the predominant serotypes of C. trachomatis in Ukraine are E, G and F, and the reduced antibody response to the first and third variable domains of serotype E was connected with lack of their exposure. The previously unknown mutation 972 T/C in omp1 gene, which has the character of synonymous substitutions, was discovered as well as the association of the severe disease with strains of C. trachomatis that contain 6 or 7 tyrosine domains in translocated actin recruiting phosphoprotein.

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Files

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dis.doc

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