Slisarenko A. Age-Related Peculiarities of the Reparative Osteogenesis Morphological Change under Cellular Dehydration (Anatomical-Experimental Research)

The research provided new data concerning functional reduction of the traumatized bone under cellular dehydration. The data depend on the animals' age and the cellular dehydration level. From the initial stages of the research young animals are characterized by the reparative osteogenesis delay and the regenerate structure change resulting in the fibroreticular connective tissue occurrence. Aged rates are characterized by the biggest disturbance of the reparative osteogenesis processes, especially on medium and high levels. The regeneration processes delay is characterized by granulation tissue increasing. During the study we observe the reduction of the chemical composition indicators and the microanalysis of the defect surface. The biggest changes occur in the shin bone regenerate of the aged rats that is not formed on the 24th day. We observe dramatic changes of the traumatized bone chemical composition leading to solidity and microhardness reduction. Mucosatum application under cellular dehydration resulted in general improvement of the regeneration process on the whole, which is also accompanied by inflammation reduction, calcium and phosphorus rise on the bones surface and level normalization of bones chemical composition.