Kononenko A. Pharmacological study of anti-inflammatory effect of the Sorbus aucuparia leaves thick extracts

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0414U002757

Thesis Registration Form

0414U002757.pdf

Applicant for

Kononenko Anna Volodymyrivna

Specialization

14.03.05 - Фармакологія

Date of defense

30-05-2014

Specialized Academic Board

Д 64.605.03

National University of Pharmacy

Essay

The thesis is devoted to the experimental study of anti-inflammatory activity of Sorbus aucuparia leaves thick extracts (SALTE). The study suggests that SALTE belonges to the VI class of toxicity – a relatively harmless substances. It was established antiexudative effect of SALTE, and conventionally effective dose of SALTE was determined, which is 100 mg/kg. It was established that SALTE has expressed anti-alterative, antioxidant, reparative, membranostabilizine, antipyretic, mild analgesic and antiexudative (on the model of adjuvant arthritis) effect. It was established that SALTE as well as silymarin, has a strong hepatoprotective and choleretic effect. Thus, the study has experimentally confirmed the prospect of creating medicines with anti-inflammatory and hepatoprotective effects based on SALTE for treatment of chronic and moderately severe inflammatory diseases of the liver and joints.

Thesis supervisor

Drogovoz Svitlana Mefodiyivna

Official opponents

Подплетня Олена Анатоліївна
Сирова Ганна Олегівна

Files

aref.doc

disser.doc

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