Aleksandrova A. Experimental substantiation of the possibility of using synthetic inhibitor of matrix metaloproteinases using in burn wounds

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0414U004952

Thesis Registration Form

0414U004952.pdf

Applicant for

Specialization

  • 14.03.05 - Фармакологія

19-11-2014

Specialized Academic Board

Д 26.550.01

Institute of Pharmacology and Toxicology of the National Academy of Medical Sciences of Ukraine

Essay

In experimental model it was shown that usage of synthetic inhibitor of matrix metalloproteinases doxycycline contributed to wound healing. In the group of rats without treatment it was shown that course of burn wound is characterized by more pronounced and longer lasting increase in proteolytic activity; increase in level of marker proinflammatory cytokines TNF- and decrease in level of anti-inflammatory cytokines IL-4; accumulation of nitric oxide metabolites; activation of processes of lipid peroxidation (increasing DC and TBA-active products), decrease antioxidant resources (activity of SOD, Cat, CP) during 28 days and it was and accompanied by disturbances of reparative regeneration, slowing of healing.

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Files

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