Nizhenkovskyi A. Pharmacodynamics and pharmacokinetics of potential cerebroprotector VITAHERM-2 in model of closed craniocerebral injury.

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0414U005651

Thesis Registration Form

0414U005651.pdf

Applicant for

Specialization

  • 14.03.05 - Фармакологія

10-12-2014

Specialized Academic Board

Д 26.550.01

Institute of Pharmacology and Toxicology of the National Academy of Medical Sciences of Ukraine

Essay

The thesis is devoted to experimental substantiation of the usefulness of the new complex compounds of germanium-based coordination bonds VITAHERM-2 as a means of drug therapy in early post-traumatic period in the model closed craniocerebral injury. Based on the results of pharmaco-metrical researches optimal dosing regimen VITAHERM-2 under its intraperitoneal administration to rats with closed craniocerebral injury: 122.94 mg / kg every 43.10 minutes of injury time. Analysis elimination VITAHERM-2 from the central chamber suggests that the closed craniocerebral injury accelerated processes of elimination, reflecting the parameters t1/2, Kel and MRT. Found that the closed craniocerebral injury increases the value of tmax, elimination half-time in urine and AUC while reducing Cmax and rate constants receipt VITAHERM-2 in urine.

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Files

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