Dementieva N. Improvement of diagnosis and treatment of haemangiomas of the skin and mucous membranes in infants

3. The presence of GLUT-1 in the HI tissue in any phase (absent in malformations) and the value of Ki-67 as a marker of HI phase were proved. The highest content of VEGF was in HI tissue and Cis C in the serum, but the difference of their se-rum levels in children with HI and healthy was absent. Activities of Cath B, L, H are higher in the serum of children with HI than in healthy, but it is impossible to use them as differential markers because of the large variability of individual values. The PR (INN)-therapy is a treatment of choice for problematic HI in infants. The own method of treatment included addi-tional safety measures and laser photothermolysis of residuals by diode laser 940 nm. Subtotal reduction of volume was ob-tained in 94.9%, color - in 66.7%, normalization of skin relief in 88.0% of patients. The method of predicting of relapse af-ter PR-therapy based on the activities of Cath B, L, H in the serum and the child's age at the start of therapy was invented. Stratification of HI for 5 risk groups and strategy for each of these groups was proposed.