Gordiychuk D. Periodontoprotective activity of acetylcysteine in experimental model of chronic generalized periodontitis

The thesis devoted to experimental substantiation of prophylactic treatment expediency by acetylcysteine in chronic generalized periodontitis. In the basis of the acetylcysteine periodontoprotective effect lies it ability to prevent membrane destruction by the significant reduction of generation and accumulation of free radicals and by the effective regulation of prooxidant-antioxidant homeostasis in serum and rats gums tissues with inflammatory-dystrophic periodontal disease. In addition, the efficiency of acetylcysteine periodontoprotective ability implemented by the stabilization performance of energy and carbohydrate metabolisms, prevention of separation processes of oxidation and phosphorylation, preservation of functional detoxication system under chronic generalized periodontitis condition. Acetylcysteine pharmacotherapeutic efficacy also consists of it’s ability to prevent and/or reduce the expression of aggressive chronic generalized periodontitis symptoms (bleeding, destruction and resorption).