Litvinenko G. Search and experimental study of the potential NSAIDs among benzofuran derivatives , 1,5-dyhidropirol-2-ones and [2,3-d]pyrimidine-6-carboxylic acid

The work is dedicated to the pharmacological study of 29 new chemical derivatives of 2,4-pyrrolidinedione (tetramic acid), [2,3-d]pyrimidine-6-carboxylic acid and benzofuran. It was found that all derivatives are low-toxic substances. Screening study conducted by antiexudative and analgesic activity. Substances VAZ- 10, L486-0021 and C764-0334 showed the significant anti-inflammatory, analgesic, antipyretic activity at the value similar to diclofenac sodium. The selected substances were not ulcerogenic and hepatotoxic action, indicating the different from other NSAIDs mechanism of action. The most effective substance L486-0021 showed chondroprotective effect in the model of adjuvant arthritis and reduced the systemic manifestations of chronic immune inflammation. The results show that the most effective substance is promising to found a new drug with a high anti-inflammatory, analgesic and chondroprotective effect and low toxicity.